E3 ubiquitin-protein ligase CBL-B is a protein in humans that is encoded by CBLB gene. E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy.

CBLB Antibodies

CBLB for Homo sapiens (Human)

CBLB Proteins

CBLB Proteins for Homo sapiens (Human)

CBLB Proteins for Mus musculus (Mouse)

CBLB Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

CBLB Proteins for Rattus norvegicus (Rat)