活性蛋白 > 其他 > Recombinant Human Membrane cofactor protein(CD46) (Active)
  • 产品名称:

    Recombinant Human Membrane cofactor protein(CD46) (Active) IN STOCK

  • 货期:
    3-7 工作日
  • uniprot号:
    P15529
  • 货号:
    CSB-MP004939HU
  • 规格:
    ¥2400
  • 图像:


    (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.



    Activity

    Measured by its binding ability in a functional ELISA. Immobilized CD46 at 2 μg/ml can bind Anti-CD46 rabbit monoclonal antibody, the EC50 of human CD46 protein is 0.8333-1.054 ng/ml.

  • 测活实验手册:
  • 分子结构:
  • 基因名称:
    CD46
  • 别名:
    TLX (Trophoblast leukocyte common antigen) (CD46)
  • 种属:
    Homo sapiens (Human)
  • 蛋白描述:
    Partial
  • 分子量:
    61.6 kDa
  • 标签信息:
    C-terminal FC-tagged
  • 来源:
    Mammalian cell
  • 纯度:
    Greater than 92% as determined by SDS-PAGE.
  • 缓冲液:
    Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4
  • 内毒素:
    Less than 1.0 EU/ug as determined by LAL method.
  • 生物活性:
    Measured by its binding ability in a functional ELISA. Immobilized CD46 at 2 μg/ml can bind Anti-CD46 rabbit monoclonal antibody, the EC50 of human CD46 protein is 0.8333-1.054 ng/ml.
  • 参考文献:
    "CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation."
    Astier A., Trescol-Biemont M.-C., Azocar O., Lamouille B., Rabourdin-Combe C.
    J. Immunol. 164:6091-6095(2000)
  • 氨基酸序列:
    CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRD
    PLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT
    FSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGK
    KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSA
    SGPRPTYKPPVSNY
  • 说明书:

    注:产品说明书可能有改进,请直接与CUSABIO产品专员联系,索取最新版说明书!

  • 简介:
    Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
    (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.
    (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3.
    (Microbial infection) Acts as a receptor for cultured Measles virus.
    (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6.
    (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).
  • 蛋白储存:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
  • 表达区域:
    35-328aa
  • 使用注意:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • 研究领域:
    Cancer