抗体 > 多克隆抗体 > DNMT1 Antibody
  • 产品类型:
    Polyclonal Antibody
  • 产品名称:

    DNMT1 Antibody

  • 货号:
    CSB-PA007082HA01HU
  • 规格:
    ¥1200
  • 别名:
    ADCADN antibody; AIM antibody; CXXC finger protein 9 antibody; CXXC-type zinc finger protein 9 antibody; CXXC9 antibody; DNA (cytosine 5 ) methyltransferase 1 antibody; DNA (cytosine-5)-methyltransferase 1 antibody; DNA methyltransferase 1 antibody; DNA methyltransferase HsaI antibody; DNA methyltransferase M.HsaI. antibody; DNA MTase antibody; DNA MTase HsaI antibody; DNMT 1 antibody; DNMT antibody; Dnmt1 antibody; DNMT1_HUMAN antibody; Dnmt1o antibody; FLJ16293 antibody; HSN1E antibody; M.HsaI antibody; MCMT antibody; Met1 antibody; MGC104992 antibody; mMmul antibody; MommeD2 antibody
  • 种属:
    Homo sapiens (Human)
  • 免疫原:
    Recombinant Human DNA (cytosine-5)-methyltransferase 1 protein (1288-1632AA)
  • 宿主:
    Rabbit
  • 种属反应性:
    Human
  • 应用范围:
    ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200
  • 背景:
    Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306).
  • 克隆类型:
    Polyclonal
  • 抗体亚型:
    IgG
  • 纯化方式:
    >95%, Protein G purified
  • 标记方式:
    Non-conjugated
  • 保存缓冲液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式:
    Liquid
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 图片:

    Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA007082HA01HU at dilution of 1:100

    Immunofluorescent analysis of HepG2 cells using CSB-PA007082HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • 说明书:
  • Accession No.:
    P26358
  • 指标名称:
    DNMT1
  • 研究领域:
    Epigenetics and Nuclear Signaling