活性蛋白 > 免疫检查点 > Recombinant Human T-lymphocyte activation antigen CD86(CD86),partial (Active)
  • 产品类型:
    Immune Checkpoint
  • 产品名称:

    Recombinant Human T-lymphocyte activation antigen CD86(CD86),partial (Active) IN STOCK

  • 货期:
    3-7 工作日
  • 英文名称:

    Recombinant Human T-lymphocyte activation antigen CD86(CD86),partial (Active)

  • uniprot号:
    P42081
  • 货号:
    CSB-AP005161HU
  • 规格:
    1mg/500μg/50μg/10μg
  • 图像:

    (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

  • 基因名称:
    CD86
  • 别名:
    Activation B7-2 antigen 3; Activation B7-2 antigen; B-lymphocyte activation antigen B7-2 2; B-lymphocyte activation antigen B7-2; B7 2; B7; B7-2; B7.2; B70; B72; B72 antigen; BU63; CD28 antigen ligand 2 2; CD28 antigen ligand 2; Cd28l2; CD28LG2; CD86; CD86 antigen (CD28 antigen ligand 2 B7 2 antigen); CD86 antigen (CD28 antigen ligand 2; B7-2 antigen) 1; 2; CD86 antigen (CD28 antigen ligand 2; B7-2 antigen); CD86 antigen; CD86 molecule; CD86_HUMAN; CLS1; CTLA-4 counter-receptor B7.2 2; CTLA-4 counter-receptor B7.2 2; 3; CTLA-4 counter-receptor B7.2; Early T-cell costimulatory molecule 1; ETC-1; FUN 1; FUN-1; FUN1; LAB72; Ly-58; Ly58; MB7; MB7-2; Membrane glycoprotein ; MGC34413; T lymphocyte activation antigen CD86 precursor; T-lymphocyte activation antigen CD86; TS/A-2
  • 种属:
    Homo sapiens (Human)
  • 蛋白描述:
    Extracellular Domain
  • 分子量:
    26.69 kDa
  • 标签信息:
    C-terminal 6xHis-tagged
  • 来源:
    Mammalian cell
  • 纯度:
    Greater than 95% as determined by SDS-PAGE.
  • 缓冲液:
    Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.2
  • 内毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    The ED50 as determined by its ability to bind Human CTLA-4 in functional ELISA is less than 20 ug/ml.
  • 参考文献:
    The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain.
  • 氨基酸序列:
    APLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSW
    TLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGY
    PEPKKMSVLLRTKNSTIEYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFS
    IELEDPQPPPDHIP
  • 说明书:

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  • 表达区域:
    24-247aa
  • 研究领域:
    Immunology
  • 引用文献:
    1. Construction of electrochemical aptasensor of carcinoembryonic antigen based on toehold-aided DNA recycling signal amplification , RenZhang,Bioelectrochemistry,2020