免疫检查点

Immune Checkpoints

免疫检查点是免疫激活的调控因子,主要在免疫应答过程中调节T细胞受体(TCR)的抗原识别。它们在维持免疫稳态和预防自身免疫方面至关重要。根据不同的免疫激活作用,免疫检查点可分为两种类型:共刺激免疫检查点和共抑制免疫检查点。共刺激免疫检查点是指一系列可以进一步刺激免疫反应的免疫检查点,如CD28,ICOS和CD137。相反,共抑制免疫检查点对抑制免疫反应的免疫检查点,如PD1,CTLA-4和VISTA。在有效的抗肿瘤免疫过程中,T细胞作为核心的执行者,首先被T细胞受体介导的抗原识别信号激活,同时众多的共刺激信号和共抑制信号精细调节T细胞反应的强度和质量。在生理情况下,共刺激分子与免疫检查点分子保持平衡,从而最大程度减少对于周围正常组织的损伤,维持对自身组织的耐受、避免自身免疫反应。而肿瘤细胞可以通过此机制,异常上调共抑制分子及其相关配体,抑制T细胞激活,从而逃避免疫杀伤。

免疫检查点产品

近几年, CUSABIO研发团队致力于靶向免疫研究,为广大科研用户开发了一系列免疫检查点重组蛋白。这些重组免疫检查点蛋白涵盖多种物种和标签,秉承客户至上的原则,所有蛋白产品在发货前我们都会对其生物活性进行再次分析和验证。另外,我们还提供蛋白质定制服务,如果您找不到您需要的蛋白质,请联系我们进行定制服务。

产品名称 货号 规格
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4(CTLA4),partial (Active) CSB-AP005121GU 1mg/500μg/50μg/10μg
Recombinant Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9),partial (Active) CSB-AP005131HU 1mg/500μg/50μg/10μg
Recombinant Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9),partial (Active) CSB-AP005141HU 1mg/500μg/50μg/10μg
Recombinant Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9),partial (Active) CSB-AP005151HU 1mg/500μg/50μg/10μg
Recombinant Human T-lymphocyte activation antigen CD86(CD86),partial (Active) CSB-AP005161HU 1mg/500μg/50μg/10μg
Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40),partial (Active) CSB-AP005171HU 1mg/500μg/50μg/10μg
Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40),partial (Active) CSB-AP005181HU 1mg/500μg/50μg/10μg
Recombinant Human CD40 ligand(CD40LG),partial (Active) CSB-AP005191HU 1mg/500μg/50μg/10μg
Recombinant Human Leukocyte surface antigen CD47(CD47),partial (Active) CSB-AP005201HU 1mg/500μg/50μg/10μg
Recombinant Human Leukocyte surface antigen CD47(CD47),partial (Active) CSB-AP005211HU 1mg/500μg/50μg/10μg
Recombinant Human CD160 antigen(CD160) (Active) CSB-AP005221HU 1mg/500μg/50μg/10μg
Recombinant Human Cytotoxic T-lymphocyte protein 4(CTLA4),partial (Active) CSB-AP005231HU 1mg/500μg/50μg/10μg
Recombinant Human Tumor necrosis factor receptor superfamily member 4(TNFRSF4),partial (Active) CSB-AP005241HU 1mg/500μg/50μg/10μg
Recombinant Human Tumor necrosis factor receptor superfamily member 4(TNFRSF4),partial (Active) CSB-AP005251HU 1mg/500μg/50μg/10μg
Recombinant Human Tumor necrosis factor ligand superfamily member 4(TNFSF4),partial (Active) CSB-AP005261HU 1mg/500μg/50μg/10μg
Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1(SIRPA),partial (Active) CSB-AP005271HU 1mg/500μg/50μg/10μg
Recombinant Human Hepatitis A virus cellular receptor 2(HAVCR2),partial (Active) CSB-AP005281HU 1mg/500μg/50μg/10μg
Recombinant Human Hepatitis A virus cellular receptor 2(HAVCR2),partial (Active) CSB-AP005291HU 1mg/500μg/50μg/10μg
Recombinant Mouse Cytotoxic T-lymphocyte protein 4(Ctla4),partial (Active) CSB-AP005301MO 1mg/500μg/50μg/10μg
Recombinant Mouse Tumor necrosis factor receptor superfamily member 14(Tnfrsf14),partial (Active) CSB-AP005311MO 1mg/500μg/50μg/10μg