SIRT1 Antibody

Datasheet
  • 货号:
    CSB-PA021339GA01HU
  • 规格:
    ¥4510
  • 其他:

产品详情

  • Uniprot No.:
  • 基因名:
    SIRT1
  • 别名:
    75SirT1 antibody; hSIR2 antibody; hSIRT1 antibody; HST2 antibody; HST2, S. cerevisiae, homolog of antibody; NAD dependent deacetylase sirtuin 1 antibody; NAD dependent protein deacetylase sirtuin 1 antibody; NAD-dependent deacetylase sirtuin-1 antibody; OTTHUMP00000198111 antibody; OTTHUMP00000198112 antibody; Regulatory protein SIR2 homolog 1 antibody; SIR1_HUMAN antibody; SIR2 antibody; SIR2 like 1 antibody; SIR2 like protein 1 antibody; SIR2, S.cerevisiae, homolog-like 1 antibody; SIR2-like protein 1 antibody; SIR2ALPHA antibody; SIR2L1 antibody; Sirt1 antibody; SirtT1 75 kDa fragment antibody; Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) antibody; Sirtuin 1 antibody; Sirtuin type 1 antibody
  • 宿主:
    Rabbit
  • 反应种属:
    Human, Mouse
  • 免疫原:
    Human SIRT1
  • 免疫原种属:
    Homo sapiens (Human)
  • 抗体亚型:
    IgG
  • 纯化方式:
    Antigen Affinity Purified
  • 浓度:
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles.
  • 产品提供形式:
    Liquid
  • 应用范围:
    ELISA, WB, IHC, IF, IP
  • 推荐稀释比:
    Application Recommended Dilution
    WB 1:500-1:1000
    IHC 1:50-1:200
    IF 1:50-1:500
  • Protocols:
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

靶点详情

  • 功能:
    NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction. Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell
  • 基因功能参考文献:
    1. These results suggest that resveratrol induces chondrosarcoma cell apoptosis via a SIRT1-activated NF-kappaB (p65 subunit of NF-kappaB complex)deacetylation and exhibits anti-chondrosarcoma activity in vivo. PMID: 28600541
    2. I157172 induced upregulation of SIRT1, and downregulation of acetyl-STAT3. PMID: 30365149
    3. SIRT1-mediated H3K9 deacetylation helps to maintain gene repression but is not required for the direct ZEB2 repressive function.SIRT1 activity maintains the stability of ZEB2-induced RAB25 repression. PMID: 30445998
    4. Data show that long non-coding RNA MALAT1 (MALAT1) repressed sirtuin 1 (SIRT1) expression through targeting forkhead box protein O1 (Foxo1). PMID: 29928873
    5. SIRT1 had a pivotally protective role in the regulation of ADSCs aging and apoptosis induced by H2O2 PMID: 29803744
    6. plasma levels correlated inversely with all studied adiposity and atherogenicity indices in metabolic syndrome patients with and without prediabetes PMID: 29779969
    7. Increased SIRT1 activity protects against diabetes-induced podocyte injury and effectively mitigates the progression of diabetic kidney disease. PMID: 29477240
    8. the Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins PMID: 28504272
    9. Adipose tissue sirtuin 1 was related to insulin sensitivity. The relationship was still present after controlling for BMI, however, it disappeared after controlling for adipose tissue SLC2A4. Muscle sirtuin 1 was not related to insulin sensitivity. PMID: 29417372
    10. data suggest that SIRT1 is an oncogenic factor in breast cancer cells and can be involved in the progression of breast cancer by inhibiting p53 and activating POLD1 PMID: 29807012
    11. SIRT1 expression is significantly upregulated in paclitaxel-resistant cervical cancer tissues and cell lines compared to normal tissues or PTX-sensitive CC tissues and cell lines. Knockdown of SIRT1 inhibited the cell proliferation, promoted cell cycle arrest and apoptosis of PTX-sensitive CC cells, and decreased the expression of MDR proteins. PMID: 29808798
    12. In our retrospective study, high SIRT1 expression significantly correlated with vascular invasion and a worse prognosis in colorectal cancer PMID: 30082156
    13. SIRT1 polymorphisms and their expression were associated with the presence of alcoholic fatty liver disease (AFLD), and there was a close relationship among four SNPs and body mass index in AFLD patients, but no SNP was related to its expression. PMID: 29189974
    14. The variable role of SIRT1 in the maintenance and differentiation of mesenchymal stem cells. PMID: 29715067
    15. Results indicate that SIRT1 may promote the metastasis of chondrosarcoma by inducing epithelial-mesenchymal transition and can be a potential molecular target for chondrosarcoma therapy. PMID: 28112277
    16. Regulation of transmembrane-4-L-six-family-1 (TM4SF1) on bladder cancer cell could be induced by peroxisome proliferator-activated receptor gamma (PPARgamma)-sirtuin 1 (SIRT1) feedback loop. PMID: 29175458
    17. Results present evidence that SIRT1 plays an essential role in regulating the transcription of CLDN5 likely by modifying and modulating the activity of KLF4 in ovarian cancer cells. PMID: 28888043
    18. results suggest that seminal SIRT1 expression has a role in male infertility PMID: 29359516
    19. SIRT1 may promote the transformation of tumor cells by inducing the epithelial-mesenchymal transition. PMID: 29656187
    20. relevance of the discovered Sirt1-Smad2 interaction for the regulation of TGFbeta-dependent gene transcription PMID: 29187201
    21. Bioinformatics and the dual luciferase reporter assay analysis results demonstrated that miR-29a specifically targeted the 3'-UTR of SIRT1 mRNA and regulated its protein expression. Increased SIRT1 expression rescued the inhibited effects induced by miR-29a overexpression in HCC cells. PMID: 29630527
    22. High Sirt1 Expression is associated with Gastric cancer. PMID: 29693338
    23. Sirt1 protects against oxidative stress-induced apoptosis in fibroblasts from psoriatic patients. PMID: 29799444
    24. Investigated the effect of statins on the expression of sirtuin 1 (SIRT1) and endothelial nitric oxide synthase 3 (eNOS) proteins in young premature myocardial infarction (PMI) patients. Found patients with PMI who were taking statins had a markedly higher level of SIRT1 compared with the controls. The level of eNOS protein was considerably lower in PMI patients compared with the control group. PMID: 29664427
    25. Clinical data are the first to identify SIRT1 as an important regulator of hepatocellular function in human liver transplants under ischemia/reperfusion stress. PMID: 28719070
    26. suggests SIRT1 may serve as a predictor of poor prognosis in esophageal squamous cell carcinoma, and its mediated tumor-promoting role might be associated with the overexpression of EGFR protein in esophageal squamous cell carcinoma PMID: 29625788
    27. findings demonstrate a new mechanism for the activation of SIRT1 under stress conditions and suggest a novel potential therapeutic target for preventing age-related diseases and extending healthspan PMID: 29133780
    28. This study represents the important role of Sirt1 and senescence in the regulation of beige adipocyte differentiation during aging. PMID: 29678576
    29. Baicalin activated the SIRT1/AMPK and mechanistic target of rapamycin (mTOR), and SIRT1/AMPK and matrix metalloproteinase (MMP) signaling in A549 and H1299 cells in a dose-dependent manner. siRNA silencing of SIRT1 and AMPK reduced the effects of baicalin on cell proliferation and migration. PMID: 29632297
    30. We provide a comprehensive overview of recent developments on the molecular signaling pathways controlled by SIRT1 and SIRT6, two post-translational modifiers proven to be valuable tools to dampen inflammation and oxidative stress at the cardiovascular levell PMID: 28661724
    31. SIRT1 was identified as a direct target of miR-212 and its expression was inversely correlated with miR-212 expression in thyroid cancer tissues. Overexpression of SIRT1 could effectively rescue miR-212 mimic-induced suppression of cell proliferation, migration and invasion in TPC-1 thyroid cancer cell line. PMID: 29207181
    32. The present study is the first to report a significant association between SIRT1 polymorphisms and antisocial personality in adolescents. PMID: 28439078
    33. Studied effects of dexamethasone on gene expression regulation of sirtuin 1 (SIRT1), interleukin 6 (IL6), and endothelin 1 (EDN1) in gingival derived aging stem cells. Dexamethasone downregulated expression of SIRT1 and IL6 but upregulated EDN1 in stem cells. PMID: 29302812
    34. miR-200a and its target gene, SIRT1, may exert a possible role in induction of apoptosis in dopaminergic neurons. PMID: 29936262
    35. The rhuschalcone I analogue (9) showed the best activity against sirt1, with an IC50 value of 40.8 microM. Based on the docking experiments, suggestions for improving the biological activities of the newly identified hit compounds have been provided. PMID: 29443909
    36. Results indicated that SIRT1 contributes to the neuroprotection of salidroside against MPP(+) -induced apoptosis and oxidative stress, in part through suppressing of mitogen-activated protein kinase (MAPK) pathways. PMID: 28851138
    37. decreased SIRT1 expression and its SUMOylation by SUMO1 and SUMO2/3 may be associated with the development of bronchopulmonary dysplasia. PMID: 29115559
    38. The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 acts as an energy sensor and negatively regulates poly(A)RNA transport via deacetylating a poly(A)-binding protein, PABP1. PMID: 28756945
    39. L-Carnitine alleviated epithelial mesenchymal transformation-associated renal fibrosis caused by perfluorooctanesulfonate through a Sirt1- and PPARgamma-dependent mechanism. PMID: 28973641
    40. High SIRT1 expression is associated with hepatocellular carcinoma. PMID: 28677784
    41. No significant association has been discovered between SIRT1 polymorphisms and diabetic foot severity or characteristics PMID: 29995800
    42. A significant correlation between the physical activity level and peripheral blood mononuclear cell SIRT1 and FOXO1 mRNA expression was found in COPD patients. PMID: 29138552
    43. Defective sirtuin-1 was found to increase IL-4 expression through acetylation of GATA-3 in patients with severe asthma compared with healthy controls. PMID: 26627546
    44. SIRT1 gene polymorphisms can have direct and indirect effects on the pathogenesis of coronary artery diseases. PMID: 29885463
    45. miR-146 exerted protective functions might be via up-regulation of Sirt1 thereby blocking NF-kappaB and Notch pathways. PMID: 29229881
    46. results suggested that SIRT1 deficiency in Bladder cancer cells could suppress cell viability by activating antioxidant response and inducing cell cycle arrest possibly via FOXO3a-related pathways. PMID: 29147649
    47. These observations provide further evidence for a critical tumor-suppressive role of the miR-200a in renal cell carcinoma (RCC) in addition to identifying a novel regulatory mechanism, which may contribute to SIRT1 upregulation in RCC. PMID: 28717923
    48. Results showed that RSV or overexpression of SIRT1 elicited inhibitory effects on NMDA-induced excitotoxicity including a decrease in cell viability, an increase in lactate dehydrogenase (LDH) release, and a decrease in the number of living cells as measured by CCK-8 assay, LDH test, and Calcein-AM and PI double staining. PMID: 29081884
    49. results indicate that FOXO1 inhibits gastric cancer (GC) growth and angiogenesis under hypoxic conditions via inactivation of the HIF-1alpha-VEGF pathway, possibly in association with SIRT1; thus, development of treatment modalities aiming at this pathway might be useful for treating GC PMID: 25761483
    50. Data suggest the activity restoration role of resveratrol toward some "loose-binding" substrates of sirtuin 1 (SIRT1), and has implications for the rational design of new substrate-specific SIRT1 modulators. PMID: 27901083

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  • 亚细胞定位:
    Nucleus, PML body, Cytoplasm, Nucleus
  • 蛋白家族:
    Sirtuin family, Class I subfamily
  • 组织特异性:
    Widely expressed.
  • 数据库链接:

    HGNC: 14929

    OMIM: 604479

    KEGG: hsa:23411

    STRING: 9606.ENSP00000212015

    UniGene: Hs.369779