APOO Antibody

Datasheet
  • 货号:
    CSB-PA001948LA01HU
  • 规格:
    ¥1320
  • 图片:
    • IHC image of CSB-PA001948LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他:

产品详情

  • 产品名称:
    Rabbit anti-Homo sapiens (Human) APOO Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    APOO
  • 别名:
    0610008C08Rik antibody; 1110019O03Rik antibody; Apolipoprotein O antibody; APOO antibody; APOO_HUMAN antibody; FAM121B antibody; Family with sequence similarity 121B antibody; MGC130105 antibody; MGC130106 antibody; MGC4825 antibody; My025 antibody; MYO25 antibody; OTTHUMP00000023073 antibody; Protein FAM121B antibody; RP23-272D10.2 antibody
  • 宿主:
    Rabbit
  • 反应种属:
    Human
  • 免疫原:
    Recombinant Human MICOS complex subunit MIC26 protein (26-198AA)
  • 免疫原种属:
    Homo sapiens (Human)
  • 标记方式:
    Non-conjugated
  • 克隆类型:
    Polyclonal
  • 抗体亚型:
    IgG
  • 纯化方式:
    >95%, Protein G purified
  • 浓度:
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式:
    Liquid
  • 应用范围:
    ELISA, IHC
  • 推荐稀释比:
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols:
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

靶点详情

  • 功能:
    Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function
  • 基因功能参考文献:
    1. The human apolipoprotein MIC26 is a bona fide subunit of the MICOS complex. PMID: 25764979
    2. It is likely that apoO participates in fatty acid metabolism and the inflammatory response in HepG2 cells. PMID: 24341743
    3. APOO represents a link between impaired mitochondrial function and cardiomyopathy onset, and targeting APOO-dependent metabolic remodeling has potential as a strategy to adjust heart metabolism and protect the myocardium from impaired contractility. PMID: 24743151
    4. relationships between plasma apoO levels and high-sensitive C-reactive protein (hs-CRP) levels, as well as other lipid parameters in healthy subjects and patients with established acute coronary syndrome PMID: 22693255
    5. apolipoprotein O is the first chondroitin sulfate chain containing apolipoprotein PMID: 16956892

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  • 亚细胞定位:
    Mitochondrion inner membrane, Single-pass membrane protein, Secreted, Mitochondrion, Golgi apparatus membrane, Endoplasmic reticulum membrane
  • 蛋白家族:
    Apolipoprotein O/MICOS complex subunit Mic27 family
  • 组织特异性:
    Expressed in all tissues examined. Up-regulated in diabetic heart.
  • 数据库链接:

    HGNC: 28727

    OMIM: 300753

    KEGG: hsa:79135

    STRING: 9606.ENSP00000368528

    UniGene: Hs.495851