Recombinant Human Parathyroid hormone protein(PTH)

In Stock
  • 货号:
    CSB-AP000051HU
  • 规格:
    ¥9822
  • 图片:
  • 其他:

产品详情

  • 纯度:
    >97% as determined by SDS-PAGE and HPLC.
  • 内毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    Fully biologically active when compared to standard. The ED50 as determined by its ability to induce cAMP accumulation in murine MC3T3E1 cells is less than 50 ng/ml, corresponding to a specific activity of >2.0x104 IU/mg.
  • 基因名:
    PTH
  • Uniprot No.:
  • 别名:
    hPTH; Parathormone; Parathyrin; Parathyroid hormone 1; Parathyroid hormone; Prepro PTH; Preproparathyroid hormone; PTH; PTH1; PTH1 receptor; PTH1R; PTHR; PTHR1; PTHY_HUMAN
  • 种属:
    Homo sapiens (Human)
  • 蛋白长度:
    Full Length of Mature Protein
  • 来源:
    E.Coli
  • 分子量:
    9.4 kDa
  • 表达区域:
    32-115aa
  • 氨基酸序列
    SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNFVALGAP LAPRDAGSQR PRKKEDNVLV ESHEKSLGEA DKADVNVLTK AKSQ
  • 蛋白标签:
    Tag-Free
  • 产品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液:
    0.2 μm filtered PBS, pH 7.4 ,lyophilized
  • 储存条件:
    Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • Datasheet & COA:
    Please contact us to get it.

靶点详情

  • 功能:
    PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
  • 基因功能参考文献:
    1. Among subjects with preserved renal function, PTH levels were possibly associated with metabolic syndrome in females, whereas vitamin D levels exhibited a possible link to metabolic syndrome in males. PMID: 29348466
    2. Data suggest that, in pregnant women with largely sufficient calcium intakes (via diet and dietary supplements), serum 25-hydroxyvitamin D (total of 25[OH]D2 and 25[OH]D3) is important for maintaining normal serum PTH levels; this study was conducted in group of white-skinned women at northern latitudes in Ireland. PMID: 30018262
    3. In conclusion, Fetuin A, vitamin D, and intact PTH levels were all associated with sarcopenia in this geriatric population. Among them, intact PTH specifically indicates patients with sarcopenic left ventricular hypertrophy. PMID: 28112206
    4. Dkk-1 and PTH levels in psoriatic arthritis are lower than healthy female controls, in contrast with rheumatoid arthritis, in which they are increased PMID: 28634697
    5. Scientific evidence of genetic association of serum PTH level among individuals with different pathologic conditions remains deficient and published results provide weak evidence (review and meta-analysis). PMID: 29794776
    6. Clinical data on secondary hyperparathyroidism, mainly derived from patients with chronic kidney disease, indicate a potential inverse association between leptin (LEP) and parathyroid hormone (PTH) in some, but not all studies. [REVIEW] PMID: 28730419
    7. Parathyroid hormone controls bone and kidney homeostasis via GNAS and Gq-G11 heterotrimeric G proteins. (Review) PMID: 28363951
    8. Patients with chronic kidney disease undergoing parathyroidectomy for primary hyperparathyroidism have similar intraoperative parathyroid hormone degradation kinetics to those with normal kidney function. PMID: 29128188
    9. PTH levels are significantly higher in untreated sustained hypertension patients than white-coat hypertension patients and normotensive subjects. PMID: 29176783
    10. results revealed that PTH treatment on HCs, either continuous or pulsatile, does not exhibit any positive effect, and indicates that exogenous PTH administration after fracture has no effect on HCs. PTH may not have a positive effect at the fracture site during the early stage of fracture healing in which haematoma formation occurs. PMID: 24039091
    11. Pre-incubation of muscle fibers or myotubes with physiological concentrations of PTH, concentration-dependently reduced uptake of labelled 25-hydroxyvitamin D3. PMID: 28104493
    12. Baseline PTH level was not associated with changes in frailty status in men. PMID: 28609827
    13. Elevated PTH induces the transition of endothelial cells to chondrogenic cells via endothelial-mesenchymal transition, possibly mediated by the nuclear translocation of beta-catenin. PMID: 27582099
    14. Cys mutation at the 25th residue of hPTH(1-34) may result in a high bone mass phenotype. PMID: 27300576
    15. Common genetic variants located near genes involved in vitamin D metabolism and calcium and renal phosphate transport associated with differences in circulating parathyroid hormone concentrations PMID: 27927781
    16. PTH pretreatment prevented TGF-beta1 and high glucose-induced Smad2/3 phosphorylation and consequent upregulation of fibronectin and type IV collagen within 4 h. PMID: 27530924
    17. FGFR1c and PTHR signaling pathways converge on NHERF1 to inhibit PTH- and FGF23-sensitive phosphate transport and down-regulate NPT2A. PMID: 27432882
    18. The present study supports the independent pathogenic effect of rs6254GA polymorphism on the development and severity of bone mineral density complications in patients with asymptomatic but not normocalcemic hyperparathyroidism. PMID: 27756092
    19. In patients receiving dual antiplatelet therapy for coronary artery disease, higher PTH levels are associated with an increased ADP-mediated platelet reactivity and suboptimal response to clopidogrel. PMID: 27086085
    20. Parathyroid hormone gene rs6256 variants are not associated with susceptibility to colorectal cancer PMID: 25124570
    21. PTH levels were significantly higher in patients with aldosterone producing adenomas. PMID: 26304960
    22. Although there was a trend for a negative association in women, no statistically significant association was found between endogenous PTH and knee osteoarthritis. PMID: 25879737
    23. The purpose of this study was to investigate the prevalence of adenomatous colon polyps (ACP) as they occur in subjects with diabetes mellitus (DM) and chronic kidney disease. PMID: 27993873
    24. PTH [parathyroid hormone]together with other markers of heart failure may provide valuable information both in the diagnosis and staging of heart failure syndromes PMID: 27546695
    25. Patients with a serum PTH decrease to low values after 1 year of hemodialysis treatment are at high risk of short-term cardiovascular death. PMID: 26880460
    26. a cell model of human dermal fibroblasts in order to investigate the functions of sclerostin, is reported. PMID: 26851122
    27. recombinant human klotho inhibits the expression of 1-OH by PTH both in vitro and in vivo. PMID: 26287968
    28. results suggest that NO-mediated vasorelaxation plays partly a role in the anabolic action of PTH on cortical bone PMID: 26834008
    29. In this large community-based cohort, PTH levels, overall, were not independently associated with the risk of hypertension. However, we found some evidence that PTH may be associated with hypertension in blacks. PMID: 26867053
    30. The objective of this article is to investigate the effect of renin-angiotensin system inhibitors (RASIs) on intact parathyroid hormone (iPTH) levels in continuous ambulatory peritoneal dialysis (CAPD) patients. PMID: 25271253
    31. PTH does not contribute to the occurrence of metabolic components of obesity, but there is a positive correlation between 25(OH)D and HDL-C. PMID: 26451492
    32. Data suggest that effects of PTH on bone remodeling are mediated not only by osteoblasts/osteocytes but also by T-lymphocytes in bone marrow; T-lymphocytes regulate differentiation/life span of stromal cells and their responsiveness to PTH. [REVIEW] PMID: 26662934
    33. Serum secreted i-PTH level might not be predictable by a total mass of parathyroid glands or by their blood supply. PMID: 26997379
    34. A Homozygous [Cys25]PTH(1-84) Mutation That Impairs PTH/PTHrP Receptor Activation Defines a Novel Form of Hypoparathyroidism. PMID: 25891861
    35. Study indicates significant association between specific PTH gene promoter region variants and altered levels of 25(OH)D and vitamin D deficiency among specific nationals. PMID: 26339419
    36. Elevation of PTH, unlike vitamin D, is independently associated with Chronic Obstructive Pulmonary Disease (COPD) severity, and may be a better biomarker for COPD. PMID: 26398210
    37. Abnormal diurnal patterns of PTH are associated with sustained mild hypercalcemia in nondialyzed chronic kidney disease patients. PMID: 27012036
    38. These data indicate that ephrinB2/EphB4 signaling within the osteoblast lineage is required for late stages of osteoblast differentiation. PMID: 23165727
    39. Serum 25(OH)D levels were inversely associated with serum PTH and bone mineral density. PMID: 23045165
    40. Elevated parathyroid hormone serum concentrations might have a role in colorectal cancer development as indicated by higher rates of adenomas, specifically with dysplasia, in women. PMID: 26021763
    41. the iPTH level in ESRD patients carrying VDR BsmI Bb genotype was higher than that in ESRD patients carrying bb genotype in overall populations and in Caucasians PMID: 25007156
    42. The identification of PTH and other hormonal resistances implies to look for the genetic disorder supporting the metabolic disorder--{REVIEW} PMID: 25913526
    43. Intraoperative PTH monitoring during parathyroidectomy to determine PTH clearance proved to be a feasible marker for adequacy and safety of surgery and "cure". PMID: 25241609
    44. Data suggest serum PTH level is independently associated with bone mineral density (BMD) in vitamin D-sufficient women and vitamin D-insufficient women; no association was found in men; high serum PTH is detrimental on BMD in postmenopausal women. PMID: 25242259
    45. In a racially/ethnically diverse population without prevalent cardiovascular disease, higher serum PTH concentration was associated with increased left ventricular mass and increased risk of incident heart failure. PMID: 25468653
    46. In a large community-based sample of elderly, calcium was independently associated with increased arterial stiffness, and PTH independently to intra-arterial peripheral and calculated central blood pressures. PMID: 25562577
    47. Suggest that measurement of iPTH may be useful for assessment of mineral bone disorder in patients with chronic kidney disease. PMID: 26299086
    48. A detailed characterization of in vitro generated amyloid fibrils from human parathyroid hormone (hPTH(1-84)). PMID: 25554227
    49. salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity. PMID: 25218037
    50. A panel of easily assessable determinants could account for both a substantial proportion of PTH variance and the occurrence of secondary hyperparathyroidism. PMID: 24202062

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  • 相关疾病:
    Hypoparathyroidism, familial isolated (FIH)
  • 亚细胞定位:
    Secreted
  • 蛋白家族:
    Parathyroid hormone family
  • 数据库链接:

    HGNC: 9606

    OMIM: 146200

    KEGG: hsa:5741

    STRING: 9606.ENSP00000282091

    UniGene: Hs.37045