Rat Caspase 3,Casp-3 ELISA Kit

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).

1. Authors reinforce the potential of CASP3 as an interesting target to be explored in adult and pediatric cHL, and alert for its dual biological role in H-RS cells and tumor microenvironment. PMID: 29901224
2. Upregulation of miR-133b-5p contributes to hypoxic preconditioning -mediated cardioprotection in cardiomyocytes, and the mechanism may be associated with inhibition of caspase-8 and caspase-3 apoptotic signaling. PMID: 29568969
3. The protein expression values of PARP and Caspase-3 in A/R cardiomyocytes were much higher than the Control. After knockdown of lncRNA AK12348, the values decreased. PMID: 29398472
4. These results indicate that CO2 may serve as a gasotransmitter to regulate cellular function by depressing MAPK and caspase 3 activities PMID: 28555276
5. Omi/HtrA2-HAX-1 chain played a significant role in mitochondrial homeostasis. PMID: 27998213
6. Studied Panax notoginseng saponins regulation of signal pathway involving mTOR/Akt, caspase-3, and miR-181b in rat model of severe acute pancreatitis. PMID: 29402262
7. the present study demonstrated that in rats with hypoxic-ischemic brain damage , there is a positive correlation between increased apoptosis of myocardial cells and expression levels of calpain-1 and caspase-3. PMID: 28447745
8. Results provide evidence for the first time for the activation of an autophagic BECN 1 gene in the medial temporal lobe cortex during 30 days after brain ischemia. The overexpression of the BECN 1 gene was accompanied by an early (during 2 days) downregulation of both BNIP 3 and caspase 3 genes. Next, during 7-30 days expression of both genes was significantly upregulated. PMID: 27472881
9. Bone marrow-derived mesenchymal stem cells mitigate caspase-3 and 8-hydroxy proline induced via beta-adrenergic agonist in pulmonary injured rats. PMID: 28266775
10. The neuroprotective effect of spermidine may be related to inhibition of the caspase 3-mediated Beclin 1 cleavage and restoration of the Beclin 1-dependent autophagy. PMID: 28383560
11. Data suggest that increase in insulin sensitivity of extensor digitorum longus muscle following low-protein, high-carbohydrate contributes to reduced proteolysis through reduction in activity of caspase-3 and ubiquitin-proteasome system. PMID: 27239756
12. BDNF pro-peptide regulates dendritic spines via CASP3. PMID: 27310873
13. Results suggest that active caspase-3 appears to mediate Purkinje cells (PC) death in the shaker mutant rat. Shaker mutant rat is a unique animal model of progressive PC degeneration, due to its compartmentalization and adult onset. Thus, caspase inhibitors might be used in an attempt to inhibit PC death in order to prevent the subsequent disease and/or ameliorate its symptoms. PMID: 28040459
14. Data indicate the role of a cathepsin-caspase 3 axis in the nuclear translocation of transcription Factor EB (TFEB) leading to lysosome biogenesis under conditions of sub-lethal oxidative stress. PMID: 28002813
15. Data show that receptor-interacting serine-threonine kinase 3 (RIPK3) played a central role in Deltamethrin (DLM)-mediated caspase 3-independent death in liver cells. PMID: 27622324
16. In summary, our results suggest that HO-1 can decrease H/R-induced myocardiac cell apoptosis; the mechanism may be related to the activation of the Akt signaling pathway and, furthermore, to the inhibition of the JNK/c-Jun/caspase-3 signaling pathway. PMID: 27220977
17. the expression of the genes that encode main pro- and antiapoptotic BAX and BCL-XL proteins, as well as caspase 3 (the main effector of apoptosis), in different brain structures of rats that were selected on a high aggression towards human (or its absence) was studied. PMID: 27830683
18. Sphallerocarpus gracilis polysaccharide protected pancreatic beta-cells from alloxan damage by several possible mechanisms, including: (1) repairing free radical damage; (2) reducing the apoptosis of pancreatic beta-cells by inhibiting the activities of caspase-3 and bax, and enhancing the activity of bcl-2; (3) stimulating insulin secretion and upregulating the pancreatic and duodenal homeobox 1 gene PMID: 27645924
19. Morin-5'-sulfonic acid sodium salt prevents changes in the expression of apoptosis related proteins caspase 3, Bax and Bcl 2 due to mercury induced oxidative stress. PMID: 27919736
20. metabolic stress induced dysfunction of the islet beta-cell may, in part, be due to defective protein prenylation signaling pathway. PMID: 27802439
21. Data show that selective activation of melanocortin 4 receptor (MC4R) decreased levels of TLR4, HMGB1 and caspase-3 mRNA in liver tissues, and significantly downregulated positive rate of NF-kappaB p65 in hepatocytes. PMID: 27412936
22. Caspase-3 expression is downregulated in rat hepatic ischemia-reperfusion injury. PMID: 27320597
23. Cytoplasmic and nuclear immunostaining for bax, caspase-3, calpain-1 and survivin proteins were found in the endometrial epithelium and stromal cells. PMID: 26818429
24. The expressions the TLR4, NF-kappaB, HMGB1, and caspase-3 were inhibited. PMID: 26806574
25. Hypoxia response element Bcl2 inhibition can effectively attenuate hypoxia-induced apoptosis resistance in pulmonary microvascular endothelial cells by downregulating Bcl2 expression and upregulating caspase-3 and P53 expression. PMID: 26456506
26. proBDNF is the predominant form of BDNF expressed in the developing rat cortex, and its expression in this brain structure correlates with the levels of active caspase-3 during perinatal development PMID: 26047381
27. The number of active caspase-3-positive neurons was significantly increased in cerebral ischemia and this was reduced markedly by exercise preconditioning. PMID: 26012958
28. Results revealed that betaII-spectrin was degraded into major fragments of 110/85 kDa by calpain-2 activation and 108/80 kDa by caspase-3 activation. PMID: 25270371
29. The data obtained suggest that the increase of caspase-3 enzyme activity could affect NEP expression via proteolytic degradation of its transcription factor AICD PMID: 26983277
30. Compared with the control group, the model and treatment groups showed significantly upregulated caspase-3, Bcl-2, and Bax mRNA and protein levels in brain tissues, but remarkably downregulated Bcl-2 mRNA and protein levels PMID: 26125843
31. Caspase-3 inhibition alleviates pulmonary injury, thereby preventing angiogenesis as well as the development of hepatopulmonary syndrome in common bile duct ligated rats. PMID: 25113058
32. These results suggest that OGD-R-induced hyperpermeability is ROS and caspase-3 dependent and can be regulated by their inhibitors. PMID: 24372803
33. Neonatal testosterone acts via ESR1 in an caspase dependent manner to suppress central pattern generators required for pulsatile oxytocin release. PMID: 24518793
34. It reduced the overexpression of the angiogenic and anti-apoptotic factors TGF-beta and Akt and improved caspase-3 expression. PMID: 25519685
35. NGF induces removal of active caspase-3 in a lysosome-dependent manner. PMID: 24787014
36. TNF-alpha released from Kupffer cells treated with LPS may induce hepatic naofen expression, which then stimulates hepatocellular apoptosis through activation of caspase-3. PMID: 24803807
37. From this current study, it can be concluded that administration of curcumin improved atrazine-induced cardiotoxicity through its modulatory effect on redox status, mitochondrial function, and caspase-3 expression. PMID: 24863870
38. Treatment with 6-OHDA increased PC12 increased caspase-3 mRNA levels by about sevenfold. CDNF pretreatment attenuated this. PMID: 24633814
39. microwave radiation induced neural cell apoptosis via the classical mitochondria-dependent caspase-3 pathway PMID: 24688304
40. Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury. PMID: 24917042
41. Lower survival in SHR cells correlated with increased DNA fragmentation, chromatin condensation, and caspase-3 activity, indicating apoptosis. PMID: 23220262
42. The rat model for GA I showed mitochondrial apoptotic pathway may be involved in the GA-induced striatal lesion. PMID: 22282255
43. The novel caspase-3 substrate Gap43 is involved in AMPA receptor endocytosis and long-term depression. PMID: 24023391
44. Myocardium Caspase-3 mRNA, SOCS-1, SOCS-3, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) expression levels and Apoptosis index in myocardium ischemia-reperfusion rats, were examined. PMID: 24091940
45. Inhibition of calpain activity also prevented caspase-3 activation. PMID: 23471945
46. Manganese treatment induced robust Sp1 phosphorylation and increased its DNA binding activity. Overexpression of mutant Sp1 lacking phosphorylation sites attenuated Sp1's ability to stimulate manganese-induced caspase-3 promoter activity. PMID: 22975163
47. Caspase-3 and GSK-3beta activation might participate in the dopaminergic cell death in a rat model of 6-hydroxydopamine induced Parkinson disease. PMID: 23940672
48. Results suggest that caspase 3 and caspase 9-dependent signaling is necessary and sufficient to promote cardiomyocyte hypertrophy. PMID: 24101493
49. S100a6/Casp gene expression between the prefrontal cortex and the cerebellum in spatial memory. PMID: 23792135
50. The intensity of active caspase-3 in the granule cell layer of dentate gyrus is associated with cell proliferation and differentiation. PMID: 22959929

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Cytoplasm

Peptidase C14A family

Expressed in heart, brain, liver, and muscle but not in kidney or testis.

KEGG: rno:25402

STRING: 10116.ENSRNOP00000014096

UniGene: Rn.10562